Program Leader(s): Steven Albelda, MD and Trevor M. Penning, PhD
The Tobacco and Environmental Carcinogenesis Program seeks to elucidate the relationships between environmental exposures and cancer by studying the molecular mechanisms of carcinogenesis, developing and validating biomarkers of carcinogen exposure and response, determining genetic susceptibility to carcinogens, and improving strategies for behavioral intervention, chemoprevention, early detection and intervention of cancers with environmental causality. The initial focus of the program is on the etiology and prevention of tobacco- and asbestos-related cancers, particularly lung cancer, head and neck cancer and mesothelioma. This research theme will become a template on which to build studies that related cancers in other organ sites with exposure to environmental carcinogens. The program includes the Center of Excellence in Environmental Toxicology (which has research themes in lung and airway disease, oxidative stress and gene environment interactions) and the Transdisciplinary Tobacco Use Research Center (which has research themes in nicotine addiction and smoking cessation.)
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